Research

KLOLIV (20 Tablets)

(Natural Joint Pain Killer and Strength Booster)

Evidence-Based Formulation

Each Tablet Contains:

• Glucosamine Sulphate = 500 mg
• Chondroitin Sulphate = 300 mg
• Methyl Sulphonyl Methane (MSM) = 500 mg
• Hyaluronic Acid = 50 mg

General Description:

Joints are cushioned by the fluid and cartilage that surround them. In some people with osteoarthritis, the cartilage breaks down and becomes thin. This results in more joint friction, pain, and stiffness. Taking the optimally designed Kloliv for Joint Health may either increase the cartilage and fluid surrounding joints or help prevent breakdown of these substances, or maybe both, resulting in relief from joint pain and symptoms of osteoarthritis. Kloliv contains four naturally occurring substances, in humans and plants, which are collectively beneficial and work in perfect synergy to improve joint health, specifically knee, hip, and spine joints. What is special about Kloliv is that it contains all ingredients in perfect dosage for optimal joint health and is manufactured with utmost care and meticulous processing in a cGMP and ISO certified facility renowned internationally.

Health Benefits:

1. Often significant relief from pain and stiffness associated with arthritis

Rheumatoid and Osteoarthritis

2. Reduces swelling and inflammation in the back, joints and muscles
3. Enhances structural integrity of the joint cartilage
4. Necessary for the formation of connective tissue to maintain joint
   flexibility and elasticity
5. Improves circulation– replaces old cells with new healthy cells
6. Reduces scar tissue
7. Improves the skin, hair and nails

Glucosamine:

Glucosamine sulfate is a chemical found in the human body. It is used by the body to produce a variety of other chemicals that are involved in building tendons, ligaments, cartilage, and the thick fluid that surrounds joints.

Studies show that supplementing glucosamine sulfate will reduce the rate of collagen (joint tissue) degradation and symptoms of osteoarthritis. Though glucosamine is comparable to acetaminophen, the reference drug for osteoarthritis, in potency. Glucosamine is very safe to supplement and its most common side-effect is flatulence. Glucosamine supplementation slows the progression of the disease.

• Glucosamine sulfate in the treatment of knee osteoarthritis symptoms: a randomized, double-blind, placebo-controlled study using acetaminophen as a side comparator. [Arthritis Rheum.2007 Feb;56(2):555-67.]

·       Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study. [Arch Intern Med. 2002 Oct 14;162(18):2113-23.]

Chondroitin Sulphate:

Chondroitin sulfate is a chemical that is normally found in cartilage around joints in the body. Chondroitin is found naturally in your body. It’s a vital part of cartilage, giving it elasticity by helping it retain water. Laboratory studies have found that chondroitin can reduce the activity of enzymes and substances that break down collagen in joints.

• Effectiveness and safety of Glucosamine, chondroitin, the two in combination, or celecoxib in the treatment of osteoarthritis of the knee. [Sci Rep. 2015; 5: 16827. Published online 2015 Nov 18. doi:  1038/srep16827]

·       The clinical effectiveness of glucosamine and chondroitin supplements in slowing or arresting progression of osteoarthritis of the knee: a systematic review and economic evaluation. [Health Technol Assess. 2009 Nov;13(52):1-148. doi: 10.3310/hta13520.]

Methylsulphonylmethane (MSM):

Methylsulfonylmethane (MSM) is a chemical found in green plants, animals, and humans. Glu, MSM and their combination produces an analgesic and anti-inflammatory effect in osteoarthritis. From increasing your energy levels to helping with conditions like allergies and asthma, MSM performs a series of important functions in your body every day.

Combination therapy showed better efficacy in reducing pain and swelling and in improving the functional ability of joints than the individual agents.

·       Comparison of Glucosamine-Chondroitin Sulfate with and without Methylsulfonylmethane in Grade I-II Knee Osteoarthritis: A Double Blind Randomized Controlled Trial. [Acta Med Indones. 2017 Apr;49(2):105-111.]

Hyaluronic Acid: 

Hyaluronic acid is a substance that is naturally present in the human body. It is found in the highest concentrations in fluids in the eyes and joints. Hyaluronic acid works by acting as a cushion and lubricant in the joints and other tissues. In addition, it might affect the way the body responds to injury.

• Oral hyaluronan relieves knee pain: a review [Nutr J. 2016; 15: 11.Published online 2016 Jan 27. Doi:  1186/s12937-016-0128-2]
• Oral Administration of Polymer Hyaluronic Acid Alleviates Symptoms of Knee Osteoarthritis: A Double-Blind, Placebo-Controlled Study over a 12-Month Period [scientificworldjournal. 2012; 2012: 167928. Published online 2012 Nov 20. Doi:  1100/2012/167928]
• Recent advances in hyaluronic acid based therapy for osteoarthritis [Clin Transl Med. 2018; 7: 6. Published online 2018 Feb 16. Doi:  1186/s40169-017-0180-3}

Dosage:

For Healthy joints and connective tissue: Three Tablets per day or as directed by the physician.

For relief in Joint pain and symptoms of Osteoarthritis: Four tablets per day or as directed by the physician.

For Maximum Joint strength in Athletes: Two tablets three times a day i.e. six tablets per 24 hours or as directed by the nutritionist.

For Hair Nail and Skin: One Tablet three times a day i.e. three tablets per day or as directed by the physician.

Note: Kloliv is a natural supplement which is proven to be completely safe in doses upto 6 tablets a day in equally divided intervals i.e. 2 tablets 3 times a day after meal. It takes 3-6 months of regular Kloliv intake for the beneficial effects in joint pain relief to be visible.